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Frederick H Hausheer Selected Research

2,2'-dithiodiethanesulfonic acid (dimesna)

3/2015Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787.
1/2015Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.
9/2010BNP7787-mediated modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro.
8/2004Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects.
8/2003Pharmacokinetics and preliminary clinical data of the novel chemoprotectant BNP7787 and cisplatin and their metabolites.
6/2003Pharmacokinetics of BNP7787 and its metabolite mesna in plasma and ascites: a case report.

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Frederick H Hausheer Research Topics

Disease

13Neoplasms (Cancer)
03/2015 - 06/2003
6Peripheral Nervous System Diseases (PNS Diseases)
12/2012 - 02/2006
5Breast Neoplasms (Breast Cancer)
12/2012 - 07/2002
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2015 - 01/2015
2Adenocarcinoma
01/2015 - 09/2010
2Nausea
09/2010 - 08/2003
2Vomiting
09/2010 - 08/2003
1Anemia
09/2010
1Lung Neoplasms (Lung Cancer)
09/2010
1Neuralgia (Stump Neuralgia)
01/2010
1Body Weight (Weight, Body)
01/2004
1Flushing
08/2003
1Ascites
06/2003
1Ovarian Neoplasms (Ovarian Cancer)
07/2002

Drug/Important Bio-Agent (IBA)

62,2'-dithiodiethanesulfonic acid (dimesna)IBA
03/2015 - 06/2003
5taxaneIBA
12/2012 - 11/2008
3Proteins (Proteins, Gene)FDA Link
03/2015 - 07/2002
3Cisplatin (Platino)FDA LinkGeneric
09/2010 - 06/2003
2Paclitaxel (Taxol)FDA LinkGeneric
09/2010 - 08/2009
2Mesna (Coenzyme M)FDA LinkGeneric
08/2004 - 06/2003
2cositecanIBA
09/2003 - 07/2002
1PlatinumIBA
09/2010
1Docetaxel (Taxotere)FDA Link
09/2010
1Oxaliplatin (Eloxatin)FDA LinkGeneric
09/2010
1Investigational DrugsIBA
09/2010
1Carboplatin (JM8)FDA LinkGeneric
09/2010
1Immunoglobulin G (IgG)IBA
01/2004
1BuffersIBA
09/2003
1purified rayonIBA
09/2003
1SolutionsIBA
09/2003
1Pharmaceutical PreparationsIBA
07/2003
1GoldIBA
06/2003
1Topotecan (Hycamtin)FDA LinkGeneric
07/2002
1CamptothecinIBA
07/2002
1Irinotecan (Camptosar)FDA LinkGeneric
07/2002

Therapy/Procedure

8Drug Therapy (Chemotherapy)
01/2015 - 02/2006
5Therapeutics
12/2012 - 07/2003
2Adjuvant Chemotherapy
12/2012 - 11/2008
1Combination Drug Therapy (Combination Chemotherapy)
09/2010
1Intravenous Infusions
08/2003
1Electrodes (Electrode)
06/2003